Associate Professor Chris John Jackson

Director, Sutton Laboratories
Medicine, Northern Clinical School
Kolling Institute of Medical Research

E25 - Royal North Shore Hospital
The University of Sydney
NSW 2006 Australia

T:	+61 2 9926 4814
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Biographical details

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Peer review

· NHMRC Grant Reviewer (~3/year past 14 years)

· NHMRC Grant Review Panel member for project grants (2007, 2011)

· NHMRC Grant Review Panel for Early Career Fellowships (2009, 2013)

· Other grant assessments include Arthritis Australia, Anti-Cancer Council of Victoria, Diabetes Australia, Israel Science Foundation, JDRF International, National Arthritis Spain.

· Reviewer for numerous journals incl. J Biol Chem, Exp Cell Res, Ann Rheum Dis, J Immunol, Arthr Rheum, Immunol, Br J Derm, J Invest Derm, J Rheum (usually >=2 each/ year)

· Editorial board; Frontiers in Bioscience, Pathobiology, Wound Practice and Research

· Managing Editor for Special Issue “Multifunctional activated protein C” in Frontiers of Bioscience 2013

· In the past 6 years he has published, as senior author, in the top-ranked journals in disciplines of:

o Dermatology -J Invest Derm 2008 (received an editorial comment)

o Arthritis-Arthr Rheum 2007, 2009, 2012 Ann Rheum Dis 2007

and other journals of note- J Biol Chem 2007, 2011; 2012, J Cell Mol Med 2009, Faseb J 2010, Cell Mol Life Sciences 2010, Am J Path 2011

· Holds 3 accepted patents (see RGMS for details) and 2 patent applications - Treatments for i) inflammatory skin disorders and ii) bone defects

Societies

· Current Vice-President, Australasian Wound and Tissue Repair Society (AWTRS, 2012-2014)

· Past President, Australian and New Zealand Microcirculation Society (ANZMS, 2005-7)

· Executive Member, Institute of Bone and Joint Research Board (since 1997)

· Key area co-ordinator (Research Advisory Committee) representing Regenerative Medicine at Royal North Shore Hospital (since 2005)

· Past Chair, Executive committee, Gore Hill Research Laboratories Animal Research and Electron Microscopy Unit, Royal North Shore Hospital

· Current society memberships: Australian Rheumatology Association, International Society on Thrombosis and Haemostasis, AWTRS, ANZMS.

Supervision

· As a senior researcher, he is committed to supervising/mentoring students and post-docs. During the past 5 years, Dr Jackson has co-supervised (including current) 10 PhD, 7 Honours students, 4 Postdoctoral fellows, 7 International Visiting Post-docs/Scholars.

· In the past 3 years, 2 PhD student for whom Dr Jackson was primary supervisor, plus 2 PhD students that Dr Jackson co-supervised and 4 Honours students have graduated.

· Currently (co-)supervising 4 PhD students, 2 Honours student and mentoring 3 post-doctoral fellows and 1 Visiting fellow.

· In 2012, Dr Jackson’s post-docs won Best ECR oral presentation at the AWTRS Scientific Meeting (Dr Kelly McKelvey) at Darling Harbour, and Best Overall Oral presentation at NSW ARA Annual Scientific Conference, Central Coast, NSW (Dr Meilang Xue).

Grants

In the past 4 years, Dr Jackson has received:

· Four NHMRC grants (three as CIA)

· JDRF International Innovative grant- C. Jackson, M Xue and L Harrison, 2008-09, US$102,000;

· Korea National Research Foundation “Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw”, Sang-Youel Park and Chris Jackson, 2010-E00019, A$100,000, 2010-2013

· Ray and PamRobinson award from Arthritis Australia in 2009 and 2013, $40,000 each

· Five University of Sydney Bridging Support grants for being CI on near miss NHMRC project grants scoring high 5 (three in 2009 and one each in 2010, 2011 and 2013 - 2 as CIA), each for $40K-$50K

Conferences

· Member, Conference organiser committees for 11 scientific conferences, currently Australian Wound and Tissue Research Society Scientific meeting, Gold Coast, 2014

· Speaker, International Vascular Biology Meeting, Weisbaden, Germany, July, 2012

· Invited speaker, Chair and Session organiser, Australian and New Zealand Microcirculation Society, Margaret River, Western Australia, Nov 2011

· Plenary speaker, South Australian Rheumatology Association Annual Scientific Meeting, Adelaide, Nov, 2010

· Invited speaker and Chair, International Microcirculation Congress, Paris, Sept 2010

· Speaker, European Tissue Repair Society, Gent, Belgium, Aug 2010

· Invited speaker, Australian Wound and Tissue Repair Society (AWTRS) Scientific Meeting, Perth, March 2010

· Invited speaker and Chair, ANZ Microcirculation Society, Queenstown, 2009

· Speaker and Chair, International Society Thrombosis and Hemostasis, Boston, 2009

· Invited speaker Australian Matrix Biology Meeting, Ettalong, Oct 2008

· Invited speaker, Inaugral AWTRS, Darwin, May 2008

Community

· Speaker, on “Rheumatoid Arthritis” at the Institute of Bone and Joint Public Forums (~200 members of public in attendance), Kolling Auditorium, Oct 2009, and Nov 2011

· Speaker, on the need for arthritis research to a large group (~4000 in attendance) of Ulysses Club members at their Annual General Meetings in Albany 2010 and Newcastle 2011

Industry

· Founder and Chief Scientific Officer - start-up company, Bioatrix, incorporated in 2012

· Attendance at the JP Morgan conference, San Francisco, Jan 2013, to present our wound healing research and upcoming clinical trials with Venture Capitalists

Translation

The research of Dr Jackson and his team has evolved to become true bench to bedside translational research. After making the original discovery, Dr Jackson has undertaken extensive basic laboratory studies, followed by animal studies to obtain proof-of-concept that APC heals chronic wounds. He then linked with his clinical colleagues to conduct open label human trials and the positive results allowed him to progress to Phase II clinical trials to use APC in diabetic chronic wounds. Dr Jackson is now poised to reveal a new contribution of APC to the field of bone healing.

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Research interests

Dr Jackson's research focuses on cellular and molecular mechanisms of inflammation in the fields of arthritis, diabetes and chronic skin disorders including burns and chronic wounds. We have a special interest in two groups of enzymes known as the matrix metalloproteinases and the serine proteases. Novel molecular biological techniques are used to manipulate cellular systems. Some interesting recent discoveries have come from our work investigating the mechanisms of action of one of these enzymes, activated protein C (APC). Our experiments using cultured cells and animal wounding models provide very strong evidence that APC accelerates wound healing. This work extends beyond cutaneous ulcers and has application to the healing of other tissues such as cartilage and bone that have been damaged by either disease, such as arthritis, or injury. Currently we are running 2 clinical trials to examine the efficacy of APC to treat chronic leg ulcers and burns. Two provisional patent applications for new therapeutic interventions have arisen from work performed in the Sutton laboratories.

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007

2013

Akbari, M., Dadadashian, F., Kordestani, S., Xue, M., Jackson, C. (2013), Enzymatic modification of regenerated cellulosic fabrics to improve bacteria sorption properties. Journal of Biomedical Materials Research. Part A. 101(6), 1734-1742. [Abstract]

2012

Lay, W., Rayner, B., Sabaretnam, T., Figtree, G., Jackson, C., Hunyor, S., Bhindi, R. (2012), Activated protein C improves left ventricular remodelling after ischemia-reperfusion injury in rats. International Journal of Cardiology. 159(3), 246-248. [Abstract]
Downey, A., Jackson, C., Harun, N., Cooper, A. (2012), Toxic epidermal necrolysis: Review of pathogenesis and management. Journal of the American Academy of Dermatology. 66(6), 995-1003. [Abstract]
Xue, M., Dervish, S., Harrison, L., Fulcher, G., Jackson, C. (2012), Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. The Journal of Biological Chemistry. 287(20), 16356-16364. [Abstract]
McKelvey, K., Xue, M., Whitmont, K., Shen, K., Cooper, A., Jackson, C. (2012), Potential anti-inflammatory treatments for chronic wounds. Wound Practice and Research. 20(2), 86-89.
Xue, M., Chan, Y., Shen, K., Dervish, S., March, L., Sambrook, P., Jackson, C. (2012), Protease activated receptor (PAR)2, rather than PAR1, contributes to the aggressive properties of synovial fibroblasts in rheumatoid arthritis. Arthritis and rheumatism. 64(1), 88-98. [Abstract]

2011

Julovi, S., Xue, M., Dervish, S., Neil Sambrook, P., Margaret March, L., Jackson, C. (2011), Protease Activated Receptor-2 Mediates Activated Protein C-Induced Cutaneous Wound Healing via Inhibition of p38. The American journal of pathology. 179(5), 2233-42. [Abstract]
Wijewardena, A., Vandervord, E., Lajevardi, S., Vandervord, J., Jackson, C. (2011), Combination of Activated Protein C and Topical Negative Pressure Rapidly Regenerates Granulation Tissue Over Exposed Bone to Heal Recalcitrant Orthopedic Wounds. The international journal of lower extremity wounds. 10(3), 146-51. [Abstract]
Seol, J., Lee, Y., Jackson, C., Sambrook, P., Park, S. (2011), Activated protein C inhibits bisphosphonate-induced endothelial cell death via the endothelial protein C receptor and nuclear factor-κB pathways. International Journal of Molecular Medicine. 27(6), 835-840. [Abstract]
Xue, M., Chow, S., Dervish, S., Chan, Y., Julovi, S., Jackson, C. (2011), Activated protein C enhances human keratinocyte barrier integrity via sequential activation of epidermal growth factor receptor and tie2. The Journal of biological chemistry. 286(8), 6742-50. [Abstract]
Julovi, S., Ito, H., Nishitani, K., Jackson, C., Nakamura, T. (2011), Hyaluronan inhibits matrix metalloproteinase-13 in human arthritic chondrocytes via CD44 and P38. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 29(2), 258-64. [Abstract]
Jackson, C., Xue, M. (2011), Anti-Inflammatory Actions of theAnticoagulant, Activated Protein C. In: Inflammatory Diseases A Modern Perspective. (pp.45-72).Croatia: InTech.

2010

Nguyen, T., Little, C., Yenson, V., Jackson, C., McCracken, S., Warning, J., Stevens, V., Gallery, E., Morris, J. (2010), Anti-IgD antibody attenuates collagen-induced arthritis by selectively depleting mature B-cells and promoting immune tolerance. Journal of autoimmunity. 35(1), 86-97. [Abstract]
Hunyor, S., Jackson, C. (2010), Microenvironment and Macroenvironment in Hypertensive Hearts. Boundaries and Silos-Can We Pick and Treat Diastolic Heart Failure?. Hypertension. 55, 1312-3. [Abstract]
Xue, M., Minhas, N., Chow, S., Dervish, S., Sambrook, P., March, L., Jackson, C. (2010), Endogenous protein C is essential for the functional integrity of human endothelial cells. Cellular and molecular life sciences : CMLS. 67(9), 1537-46. [Abstract]
Minhas, N., Xue, M., Fukudome, K., Jackson, C. (2010), Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(3), 873-81. [Abstract]
Moon, M., Seol, J., Seo, J., Jeong, J., Lee, Y., Kim, I., Jackson, C., Sambrook, P., Park, S. (2010), Protective effect of hypoxia on bisphosphonate-related bone cell damage. Molecular Medicine Reports. 3(5), 869-875. [Abstract]

2009

Xue, M., Smith, M., Little, C., Sambrook, P., March, L., Jackson, C. (2009), Activated Protein C Mediates a Healing Phenotype In Cultured Tenocytes. Journal of cellular and molecular medicine. 13(4), 749-57. [Abstract]
Jackson, M., Smith, M., Smith, S., Jackson, C., Xue, M., Little, C. (2009), Activation of cartilage matrix metalloproteinases by activated protein C. Arthritis and Rheumatism. 60(3), 780-791. [Abstract]
Xue, A., Xue, M., Jackson, C., Smith, R. (2009), Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling. The international journal of biochemistry & cell biology. 41(8-9), 1731-1738. [Abstract]

2008

Xue, M., Jackson, C. (2008), Autocrine Actions of Matrix Metalloproteinase (MMP)-2 Counter the Effects of MMP-9 to Promote Survival and Prevent Terminal Differentiation of Cultured Human Keratinocytes. The Journal of investigative dermatology. 128(11), 2676-85. [Abstract]
Whitmont, K., Reid, I., Tritton, S., March, L., Xue, M., Lee, M., Fulcher, G., Sambrook, P., Slobedman, E., Cooper, A., Jackson, C. (2008), Treatment of chronic leg ulcers with topical activated protein C. Archives of Dermatology. 144(11), 1479-1483. [Abstract]
Jackson, C., Whitmont, K., Tritton, S., March, L., Sambrook, P., Xue, M. (2008), New therapeutic applications for the anticoagulant, activated protein C. Expert Opinion on Biological Therapy. 8(8), 1109-1122. [Abstract]
Xue, A., Scarlett, C., Jackson, C., Allen, B., Smith, R. (2008), Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. Pancreas. 36(2), 160-167. [Abstract]
Jackson, C., Xue, M. (2008), Activated protein C-An anticoagulant that does more than stop clots. The international journal of biochemistry & cell biology. 40(12), 2692-7. [Abstract]
Xie, L., Galettis, A., Morris, J., Jackson, C., Twigg, S., Gallery, E. (2008), Intercellular adhesion molecule-1 (ICAM-1) expression is necessary for monocyte adhesion to the placental bed endothelium and is increased in type 1 diabetic human pregnancy. Diabetes/metabolism research and reviews. 24(0), 294-300. [Abstract]

2007

Xue, M., March, L., Sambrook, P., Fukudome, K., Jackson, C. (2007), Endothelial protein C receptor is over-expressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Annals of the rheumatic diseases. 66(12), 1574-80. [Abstract]
Wang, Y., Chang, H., Wertheim, D., Jones, A., Jackson, C., Coombes, A. (2007), Characterisation of the macroporosity of polycaprolactone-based biocomposites and release kinetics for drug delivery. Biomaterials. 28(31), 4619-27. [Abstract]
Xue, M., March, L., Sambrook, P., Jackson, C. (2007), Differential regulation of matrix metalloproteinase 2 and matrix metalloproteinase 9 by activated protein C: Relevance to inflammation in rheumatoid arthritis. Arthritis and rheumatism. 56(9), 2864-74. [Abstract]
Xue, M., Campbell, D., Jackson, C. (2007), Protein C is an autocrine growth factor for human skin keratinocytes. The Journal of biological chemistry. 282(18), 13610-13616. [Abstract]
Gallagher, G., Menzie, S., Huang, Y., Jackson, C., Hunyor, S. (2007), Regional cardiac dysfunction is associated with specific alterations in inflammatory cytokines and matrix metalloproteinases after acute myocardial infarction in sheep. Basic research in cardiology. 102, 63-72. [Abstract]
Gallagher, G., Jackson, C., Hunyor, S. (2007), Myocardial extracellular matrix remodeling in ischemic heart failure. Frontiers in bioscience : a journal and virtual library. 12(4), 1410-1419. [Abstract]
Le, N., Xue, M., Castelnoble, L., Jackson, C. (2007), The dual personalities of matrix metalloproteinases in inflammation. Frontiers in bioscience : a journal and virtual library. 12, 1475-1487. [Abstract]

Current national competitive grants*

2012

Efficacy of Activated protein C to treat Diabetic Leg ulcers - a randomised, controlled clinical trial
Jackson C, Fulcher G, Wraight P, March L, Cooper A
NHMRC Project Grants ($500,496 over 3 years)

2010

Role of Activated protein C in treatment of bisphosphonate-induced diseases including osteonecrosis of the jaw
Jackson C, Park S, Sambrook P
Korean Research Foundation Research Support ($93,000 over 3 years)

* Grants administered through the University of Sydney

Kolling Institute for Medical Research - Medical research matters